Jack Wilshere will have tests on Tuesday to assess the damage to his left ankle with the injury-plagued West Ham midfielder ruled out of Sunday's trip to Everton.
On Friday, manager Manuel Pellegrini confirmed Sportsmail's story that Wilshere, 26, has missed training this week after suffering another setback.
He was signed after leaving Arsenal as a free agent in the summer having endured several seasons when ankle problems sidelined him.
'Jack felt a pain in his ankle two days ago,' Pellegrini said. 'He doesn't have a chance (to face Everton). On Tuesday we will see after he has a medical review.'
Pellegrini, whose team are bottom after four defeats, dismissed talk he is angry about team news being leaked before matches.
'I don't worry about that,' he said. 'I worry about trying to win three points.'
He has told his players not to fear his philosophy because two examples from his 35 years as a coach prove he knows best. The 64-year-old Chilean has overseen four consecutive Premier League defeats.
Pellegrini discussed the teething problems he also endured at Villarreal and Malaga, before later leading them into uncharted territory in the Champions League.
'I started with Villarreal and we had three points from the first 15, then we finished third in the table,' said the ex-Manchester City boss.
'After that with Malaga, when I arrived the team were in the relegation zone. We lost five or six games in a row but we continued in the same way. I am more confident than ever.
'In the five years I was at Villarreal, every time I had the same problem. We finished second, we finished third, we finished fifth. Semi-finals of the Champions League. At every club you have a bad moment in the season.
'They must understand, they must trust in what we are doing because it is not an experiment we are doing here. I will not change.
'Doubt my methods? No. I always trust in what I do because, I repeat, I have 35 years in this.'